Prospective, non-comparative, non-interventional, observational study to collect and analyse real life environment data on advanced prostate cancer patients receiving combination treatment of medical or surgical castration and bicalutamide according to routine medical practice in Croatia. The main aim is to evaluate change of PSA level and prescribing practices based on prostate cancer stage.

Inclusion Criteria:

• Patients with diagnosis of advanced prostate cancer
• Patients who are already treated with bicalutamide for at least 4 weeks and maximum 12 weeks
• Patients capable of signing ICF

Exclusion Criteria:

• Patients with hypersensitivity to bicalutamide
• Patients on therapy with terfenadin, astemizol or cisapride
• Participation in a clinical study during the last 30 days

400 advanced prostate cancer patients (outpatients or hospitalized) treated with bicalutamide in combination with medical or surgical castration according to standard clinical practice