Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Randomized Clinical Trial Comparing Propofol and Midazolam in Mechanically Ventilated Critically Ill Patients With Alcohol Use Disorders: An Open Label Pilot Study

The aim of this study is to evaluate the effects of the sedatives propofol and midazolam on stress response and immune function in critically ill patients with alcohol use disorders who are undergoing mechanical ventilation.

No detailed description

Inclusion Criteria:

• Diagnosis of alcohol use disorders
• Need for invasive mechanical ventilation
• Need for continuous intravenous infusion of sedative(s)

Exclusion Criteria:

• Age < 18 years
• Pregnant women
• Prisoners
• Receiving propofol prior to randomization
• Patient experiencing active alcohol withdrawal
• Immunosuppression
• Shock
• Attending physician does not feel patient is candidate to receive either propofol or midazolam
• Patient has contraindication(s) to receiving either propofol or midazolam
• Inability to enroll patient within 96 hours after initiation of mechanical ventilation
• Transfer from another intensive care unit