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PI left University
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To follow the patterns and natural history of Islet Transplant recipients (the ones that were involved in the Modified Edmonton Protocol) using oral glucose to check sugar levels as well as insulin and C-peptide over the course of 5 years
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Islet Recipient | Subjects that have successfully received and maintained an Islet transplant at Washington University Center for Islet Transplantation |
| |
| Control | subjects that were similar in height, weight and age that did NOT have diabetes to act as the comparative group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OGTT (Oral Glucose Tolerance Test) | Other | Subjects would consume 75grams of sugar (Dextrose, 10 oz) and blood samples taken at specified time points to measure glucose, insulin and C-peptide |
| Measure | Description | Time Frame |
|---|---|---|
| OGTT will be performed every 6 months for 5 years in subjects with a functioning Islet Transplant | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| The OGTT reflects the function of the Islet transplant and could be used as an indication of Islet Transplant function | 5yrs |
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Inclusion Criteria:
Exclusion Criteria:
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Type 1 diabetics that have successfully received and maintained an islet transplant here at Washington University. Loss of transplant function is an exclusion criteria.
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| Name | Affiliation | Role |
|---|---|---|
| Kenneth S Polonsky, MD | Washington University School of Medicine | Principal Investigator |
| Daniel C Brennan, MD | Washington University School of Medicine | Principal Investigator |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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Serum samples are obtained during the OGTT and stored in a -20degree freezer. They are tested for Insulin C-peptide and glucose.
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |