Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans: A Pilot Study, and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.

Inclusion Criteria:

• Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation
• May undergo radiation therapy
• Patient and/or guardian is able to provide written informed consent prior to study registration
• Age ≥ 18 years old

Exclusion Criteria:

• Extreme claustrophobia that precludes MRI scan
• Known allergic reaction to Gd-DTPA
• Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines
• Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).
• Pregnant or nursing female
• Unable to cooperate for MRI and/or radiation therapy planning