Trial of Montelukast for Treatment of Acute Bronchiolitis

A Randomized, Double Blind, Placebo Controlled Trial of Daily Montelukast for the Treatment of Viral Bronchiolitis

The primary rationale for this study is to evaluate the effect of once daily montelukast on duration of acute illness in infants with first-time bronchiolitis.

Inclusion Criteria:

• Male or female infants aged 3 to 12 months of age
• Diagnosis by emergency physician of bronchiolitis

Exclusion Criteria:

• Any previous episode, as determined by a physician, of wheezing, bronchiolitis or asthma
• Any history of previous bronchodilator use prior to this illness
• Treatment with corticosteroids in the 14 days prior to the current illness
• Immunosuppression
• Immunodeficiency
• Caregiver does not speak English
• Diagnosis by the treating ED physician of croup
• Diagnosis by the treating ED physician of pneumonia
• Caregiver does not have access to a telephone