Circulating microRNAs as Biomarkers of Sepsis

Diagnostic and Predictive Value of Circulating microRNAs During Sepsis

MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

Inclusion Criteria:

• patients who develop sepsis and undergo abdominal surgery
• patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

• patients with a primary diagnosis of acute pancreatitis
• patients with cirrhosis or renal dysfunction
• patients with dyscrasia
• patients with autoimmunity diseases
• patients with severe cardiac and pulmonary diseases
• patients with hematological diseases
• patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass