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The purpose of this study is to compare the effects of pitavastatin and atorvastatin on adiponectin percentage change in patients with hypercholesteremia comorbid stable CAD.
The efficiency of lipid lowering therapy was already proven by the clinical trials of statins. According to these results, the target value of LDL-C is recommended under 100mg/dL in the Japan Atherosclerosis Society Guidelines. However, the efficiency of intensive therapy to lower LDL-C more than 100mg/dL has not been proven yet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | pitavastatin group |
|
| 2 | Active Comparator | atorvastatin group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pitavastatin | Drug | comparison of two drugs in increasing HDL-C and adiponectin |
| |
| Measure | Description | Time Frame |
|---|---|---|
| HDL-cholesterol (HDL-C); Adiponectin; High-Molecular- Weight Adiponectin(HMW Adiponectin) | start, 6 months, 12 months, 30 months |
| Measure | Description | Time Frame |
|---|---|---|
| TC; LDL-C; HDL-C; HDL2-C; HDL3-C; TG; smalldenseLDL; MDA-LDL; FPG; HbA1c; Cr; RLP-C; apoA-I; apoB; apoC-â…¡; apoC-â…¢ | start, 6 months, 12 months, 30 months |
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Inclusion Criteria:
Patients with dyslipidemia as defined by any of the parameters:
Patients who passed three months or more after acute myocardial infarction
Patients who passed one month or more after unstable angina
Patients who passed one month or more after PCI
Patients with written consent by their own volition after being provided sufficient explanation for the participation into this clinical trial
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hisao Ogawa, MD,PhD | Kumamoto University Graduate School of Medical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kumamoto University Graduate School of Medical Sciences Department of Cardiocascular Medicine | Kumamoto | Kumamoto | 860-8556 | Japan |
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| Atorvastatin |
| Drug |
comparison of two drugs in increasing HDL-C and adiponectin |
|
| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| C108475 | pitavastatin |
| D000069059 | Atorvastatin |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006538 | Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |
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