Does Thiamine Help Vomiting and Nausea in Pregnancy?

Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy

There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.

• Research groups: pregnant women eho visit the emergency room for nausea and vomiting in pregnancy, pregnancy age 12 weeks or less
• After basic examinations and hydration, the women will randomized to thiamine or promethazine treatment.
• If no improvement is shown, the patient will be treated with the other drug
• The patients will be interviewed on their current visit and every two weeks until 14th week of gestation
• The interview includes medical history and details about their illness, other treatments, hospitalization etc.

Inclusion Criteria:

• Pregnant women until 12th week of gestation
• The women visit the ER because of nausea and vomiting
• The women didn't received thiamine yet

Exclusion Criteria:

• Pregnant women over 12th week of gestation
• Women that received thiamine before
• women that allergic to the studied drugs