The purpose of this study is to evaluate the Veritas Collagen Matrix in treating female patients with documented occurence of Pelvic Organ Prolapse as evidenced by a cystocele.

Surgery for cystocele repair to be performed. Native tissue repair to be randomized versus reinforcement with Collagen matrix

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Inclusion Criteria:

• Patient is equal or greater than 18 years old
• Female
• Meets follow-up evaluation time frame
• Understands the nature of the procedure and has provided written informed consent
• Is scheduled to undergo vaginal pelvic reconstructive surgery
• Has > 2nd degree midline cystocele

Exclusion Criteria:

• Presence of severe mucosal ulceration
• Previous pelvic organ prolapse surgery using an implant that will affect the use of the VCM or affect the outcome of the study
• Allergy to bovine material
• Severe mucosal atrophy
• Shortened vaginal length as determined by Investigator
• Pregnant or intends to become pregnant during study
• Has a UTI
• Has vault prolapse < 2nd degree cystocele