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Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.
To our knowledge no data are available on the effect of goal-directed fluid therapy on hemodynamics in lean patients and obese patients, respectively. Consequently, we want to compare lean patients (BMI <25) vs. obese patients (BMI >25) in regard of their respective needs for intraoperative fluid therapy, and the impact of the goal-directed fluid regimen on tissue oxygenation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ringerlactate lean | Active Comparator | fluidtherapy with crystalloids in lean patients |
|
| Ringerlactate overweight | Active Comparator | fluidtherapy with crystalloids in overweight patients |
|
| Ringerlactate obese | Active Comparator | fluidtherapy with crystalloids in obese patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluidotherapy with ringer-lactate | Drug | a bolus of 250ml ringer-lactate is administered, if there is fluid demand monitored by the Esophageal Doppler |
|
| Measure | Description | Time Frame |
|---|---|---|
| different hemodynamic fluid responses in the different groups | every 10 minutes during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Subcutaneous oxygen tension (PsqO2) | every 10 minutes during surgery and 2 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrea Holzer, MD | Medical University Vienna, Department of Anesthesiology and General Intensive Care Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University Vienna | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12357146 | Background | Gan TJ, Soppitt A, Maroof M, el-Moalem H, Robertson KM, Moretti E, Dwane P, Glass PS. Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology. 2002 Oct;97(4):820-6. doi: 10.1097/00000542-200210000-00012. |
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| ID | Term |
|---|---|
| D000077325 | Ringer's Lactate |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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