Goal Directed Fluid Therapy

Intraoperative Goal Directed Fluid Therapy in Lean and Obese Patients

Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.

To our knowledge no data are available on the effect of goal-directed fluid therapy on hemodynamics in lean patients and obese patients, respectively. Consequently, we want to compare lean patients (BMI <25) vs. obese patients (BMI >25) in regard of their respective needs for intraoperative fluid therapy, and the impact of the goal-directed fluid regimen on tissue oxygenation.

Inclusion Criteria:

• female patients (18 - 80 years) undergoing elective gynecological open surgery (hysterectomy, ovarian cysts and tumors, myomectomy, endometriosis)

Exclusion Criteria:

• cardiac insufficiency (EF< 35%)
• renal insufficiency (creatinin clearance <30ml/min, dialysis)
• insulin dependant diabetes mellitus
• coagulopathy
• NYHA IV
• infection
• sepsis
• history of suspect malignant hyperthermia
• porphyria