Early Response to Interferon Combined Short-Term Nucleoside Analogue Therapy in HBeAg(+) Chronic Hepatitis B

Early Response to Interferon Combined Short-Term Nucleoside Analogue Therapy in HBeAg(+) Chronic Hepatitis B

For HBeAg(+) patients, interferon is used for 12 weeks. On 12th week of treatment, If HBV DNA is undetectable (<1000 copies/ml), interferon is continued alone for one year. If HBV DNA is still positive, nucleoside analogue is added for 3 months. After nucleoside analogue is added for 3 months, HBV DNA is tested again. If negative, stop nucleoside analogue and use interferon alone for another 6 months or longer. If HBV DNA is still positive, change to another nucleoside analogue or add another nucleoside analogue.

Inclusion Criteria:

• HBsAg posive for 6 months
• HBeAg positive, and HBeAb negative
• HBV DNA>1.0×E5 copies/ml
• ALT>80 u/L within 3 months

Exclusion Criteria:

• pregnant women
• conbination infection of HCV, HAV, or HEV
• conbination infection of HIV
• any contraindication of interferon α