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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL050420 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Pennington Biomedical Research Center | OTHER |
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Studies have shown that phytosterols will lower LDL cholesterol. Typical diets can contain between 250 to 500 mg of naturally-occurring phytosterols. Long-term studies with phytosterol-containing products(such as margarines) have not taken into account the amounts of naturally occurring phytosterols in the diet. This means that the effects of small amounts of natural dietary phytosterols on LDL cholesterol are not known. In this study, we will examine the effects of phytosterols across a range of levels. The information will likely be used to further support and possibly extend the current dietary recommendations for phytosterol use.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Medium Phytosterols | Experimental | Diets with daily 400 mg of phytosterols |
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| High Phytosterols Diet | Experimental | Diet with 2000 mg of daily phytosterols |
|
| Low Phyto Diet | Placebo Comparator | Diet with less than 100 mg of daily phytosterols |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Different amount of phytosterols are added into diets | Dietary Supplement | Diets with 59, 400, or 2000 mg of phytosterols daily for 4 weeks were given to each subject, in random order. |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal cholesterol excretion | At the end of week 4 on each diet |
| Measure | Description | Time Frame |
|---|---|---|
| intestinal cholesterol absorption | At the end of week 4 on each diet |
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Inclusion Criteria:
Men and women are eligible who:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Richard Ostlund, MD | Washington University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19889819 | Result | Racette SB, Lin X, Lefevre M, Spearie CA, Most MM, Ma L, Ostlund RE Jr. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr. 2010 Jan;91(1):32-8. doi: 10.3945/ajcn.2009.28070. Epub 2009 Nov 4. |
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| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |