Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Previous studies have indicated that menaquinone-7 (MK-7) is the most effective form of vitamin K. The Japanese soya product natto is one of the richest food sources of MK-7, but its taste is not appreciated by the Western society. For this reason, the active biological compound has been manufactured as enriched oil or casein (≈80% of proteins in cow's milk)-enriched powder. However, cow's milk allergy is the most common cause of food allergy affecting a minimum of 2-3% of infants. The investigators will therefore compare this protein-delivery system to an alternative delivery system (Arabic gum; 98% polysaccharides). To compare the difference between powder and oil as MK-7 delivery vehicle, the investigators will also test the efficacy of enriched linseed oil.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | 2 casein capsules per day existing of 90 µg menaquinone-7 per day for 8 weeks |
|
| 2 | Active Comparator | 2 arabic gum capsules per day existing of 90 µg menaquinone-7 per day for 8 weeks |
|
| 3 | Active Comparator | 2 linseed capsules existing of 90 µg menaquinone-7 per day for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| menaquinone-7 from casein capsules | Dietary Supplement | 90 µg menaquinone-7 daily during 8 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| serum level menaquinone-7 | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| plasma level of biochemical markers carboxylated matrix-Gla protein, undercarboxylated matrix-Gla protein, carboxylated osteocalcin, undercarboxylated osteocalcin | 8 weeks |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Cees Vermeer, PhD | VitaK /University of Maastricht | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VitaK BV /University of Maastricht | Maastricht | PO Box 616 | Netherlands |
Not provided
Not provided
Not provided
Not provided
Not provided
| menaquinone-7 from arabic gum capsules |
| Dietary Supplement |
90 µg menaquinone-7 daily during 8 weeks |
|
| menaquinone-7 from linseed oil capsules | Dietary Supplement | 90 µg menaquinone-7 daily during 8 weeks |
|