Pharmacokinetic Study of Daptomycin in Healthy Chinese Subjects Living in China

A Two Cohort, Open Label, Single and Multiple Dose Pharmacokinetic Study of 4mg/Kg and 6mg/Kg Doses of Daptomycin in Healthy Chinese Subjects Living in China

The primary objective of this study is to characterise the pharmacokinetics and dose proportionality of daptomycin after single and multiple (once daily) 4mg/kg and 6 mg/kg doses of daptomycin in healthy Chinese volunteers.

Inclusion Criteria:

• Men or women (not of childbearing potential) of Chinese ethnicity
• Weight between 55Kg to 90Kg and have a Body Mass Index (BMI) between 18 and 25 kg/m2
• Have a calculated creatinine clearance within range from 80 to 120 ml/min inclusive

Exclusion Criteria:

• Unable to discontinue use of HMG-CoA reductase inhibitor therapy within 7 days prior to first dose of study drug through discharge from unit
• CPK > 2X ULN (upper limit of normal)