Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.

Inclusion Criteria:

• Sedentary
• Obese
• Have either dyslipidemia (HDL < 50 or triglycerides > 150), waist circumference > 88cm, and impaired glucose tolerance or homeostasis model assessment value of > 3
• Subjects with HIV-MS must have been receiving HAART for > 6 months

Exclusion Criteria:

• Medication changes in the last 3 months
• Diabetes mellitus
• Medical problems that in the opinion of the principal investigator may interfere with patient safety
• Substance abuse