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| ID | Type | Description | Link |
|---|---|---|---|
| 2R01HL062705-05A2 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.
The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.
During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| African American Families | Families with 2 parents and 2 children - no intervention, observational study |
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| Caucasian Families | Families with 2 parents and 2 children - no intervention, observational study |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention, observational study | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Genetic variation of Lp(a) levels in each group | five years |
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Inclusion Criteria:
Exclusion Criteria:
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We are recruiting 100 African American and 100 Caucasian families. The families that will be recruited will have two natural parents and two natural offspring.
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| Name | Affiliation | Role |
|---|---|---|
| Lars Berglund, M.D., Ph.D. | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC Davis CTSC Clinical Research Center (CCRC) at Veterans Affair Medical Center | Mather | California | 95655 | United States |
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| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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plasma, DNA, white blood cell