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Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1% lidocaine with 1:100000 adrenaline | Active Comparator | high dose adrenaline |
|
| 1% lidocaine with 1:200,000 adrenaline | Active Comparator | low dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1% lidocaine with 1:100,000 adrenaline | Drug | high dose |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of Intraoperative bleeding | during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamic fluctuation | during surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Moshaver, MD | Contact | 250-276-5050 | moshaver@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Ali Moshaver, MD | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Toronto | Toronto | Ontario | M6R 1B5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19841339 | Derived | Moshaver A, Lin D, Pinto R, Witterick IJ. The hemostatic and hemodynamic effects of epinephrine during endoscopic sinus surgery: a randomized clinical trial. Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):1005-9. doi: 10.1001/archoto.2009.144. |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D004837 | Epinephrine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| 1% lidocaine with 1:200,000 adrenaline |
| Drug |
1% lidocaine with 1:200,000 adrenaline |
|
| Aniline Compounds |
| D000588 | Amines |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |