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| Name | Class |
|---|---|
| Cancer Australia Priority-driven Collaborative Cancer Research Scheme | UNKNOWN |
| The University of Queensland | OTHER |
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Ovarian cancer patients are often at risk of malnutrition because of weight loss, lack of appetite and reduced food intake. Being malnourished can contribute to the incidence and severity of cancer treatment side effects and increase the risk of infection. Currently patients with advanced ovarian cancer do not receive early nutrition using a feeding tube.
The purpose of this study is to compare enteral nutrition along with standard post-surgery care against current standard post-operative care alone. This study will see if early nutrition using a feeding tube has an impact on length of hospital admission, recovery from surgery, complications from surgery, nutritional status and ultimately a reduction in treatment costs in people with Advanced Epithelial Ovarian Cancer (EOC). Primary Peritoneal Cancer (PPC) or Fallopian Tube Cancer. Nutritional support has been shown to ;
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early post-operative enteral feeding | Experimental | Standard post-operative care and diet together with early post-operative enteral feeding |
|
| Standard post-operative care and diet | No Intervention | Standard post-operative care and diet only |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early post-operative enteral feeding | Dietary Supplement | During primary surgical treatment an enteral feeding tube will be inserted through the patient's nose into their small bowel. Enteral feeding will commence 4 hours following return to ward from surgery. Feeding will start at a rate of 40 ml/hr for the first 24 hours, and then increased to goal weight. Goal will be calculated by 125 kiloJoules/kilogram adjusted body weight. |
| Measure | Description | Time Frame |
|---|---|---|
| Cost outcomes as represented by length of stay and cost effectiveness of enteral feeding / Quality of life | Compare treatment costs and cost effectiveness between early enteral feeding with standard post-operative care versus current standard ost-operative care for advanced epithelial ovarian cancer. Compare quality of life after surgery between women who receive early enteral feeding along with standard post-operative care versus those who receive current standard post-operative care for advanced epithelial ovarian cancer | End of study |
| Measure | Description | Time Frame |
|---|---|---|
| length of stay | Length of stay in an intensive care unit or high dependency unit and overall length of hospital stay. | Until discharge from hospital |
| Need for inotropic medications and intravenous treatment requirements |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andreas Obermair, MD FRANZCOG CGO | Queensland Centre for Gynaecological Cancer | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Wesley Hospital | Auchenflower | Queensland | 4066 | Australia | ||
| Brisbane Private Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25827292 | Derived | Baker J, Janda M, Graves N, Bauer J, Banks M, Garrett A, Chetty N, Crandon AJ, Land R, Nascimento M, Nicklin JL, Perrin LC, Obermair A. Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial. Gynecol Oncol. 2015 Jun;137(3):516-22. doi: 10.1016/j.ygyno.2015.03.048. Epub 2015 Mar 28. |
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|
| Until discharge from hospital |
| Nutritional status 6 weeks after surgery | 6 weeks after surgery |
| Treatment related adverse events | End of study |
| Delay and dose reductions of chemotherapy / quality of life during chemotherapy | End of study |
| Brisbane |
| Queensland |
| 4000 |
| Australia |
| Greenslopes Private Hospital | Greenslopes | Queensland | 4120 | Australia |
| Royal Brisbane and Women's Hospital | Herston | Queensland | 4029 | Australia |
| Mater Health Services | South Brisbane | Queensland | 4101 | Australia |
| Gold Coast Hospital | Southport | Queensland | 4215 | Australia |
| ID | Term |
|---|---|
| D000077216 | Carcinoma, Ovarian Epithelial |
| D005185 | Fallopian Tube Neoplasms |
| D010051 | Ovarian Neoplasms |
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |
| D005184 | Fallopian Tube Diseases |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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