Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy

Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis

Actinic cheilitis is a common precancerous lesion of the lip. The purpose of this study is to compare imiquimod 5% therapy and photodynamic therapy. The data will include effect data, histology (skin analysis), epidemiological data and follow-up data.

Randomized study comparing imiquimod 5% with photodynamic therapy for actinic cheilitis. Histological, efficacy, epidemiological and clinical data will be collected.

Inclusion Criteria:

• Clinical findings of actinic cheilitis.
• Histological findings demonstrating epithelial changes equal to or greater than mild epithelial dysplasia in severity (mild - moderate - severe).
• Age above 18.
• Willingness to take post-treatment biopsy.

Exclusion Criteria:

• Disorders predisposing to photosensitivity (porphyria, SLE).
• Pregnancy or nursing.
• Known allergy to any excipients in the study creams.
• prescribed topical retinoids, 5-fluorouracil, cryodestruction, surgical excision and curettage.