Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate

Comparative Effects of Nebivolol Versus Metoprolol on 24-hour Blood Pressures and Basal Metabolic Rate: An Open-Label Study

The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.

Inclusion Criteria:

• 18 years old or older
• currently be treated at a University of MS Medical Center Internal Medicine Clinics
• currently taking metoprolol succinate for hypertension
• have their hypertension controlled (<140/90).

Exclusion Criteria:

• uncontrolled hypertension
• severe renal or moderate hepatic impairment
• currently taking CYP 2D6 inducers/inhibitors
• recent stroke (less than 6 months)
• recent myocardial infarction (less than 6 months)
• congestive heart failure
• diagnosed obstructive sleep apnea
• atrial fibrillation
• arm circumference >50 cm