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| ID | Type | Description | Link |
|---|---|---|---|
| 4265 | Other Identifier | Legacy IRB number |
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| Name | Class |
|---|---|
| Roche-Genentech | INDUSTRY |
| Novartis | INDUSTRY |
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The purpose of this study is to determine if RAD001 (everolimus) helps improve the standard treatment of XELOX-A (bevacizumab, oxaliplatin, capecitabine) in advanced solid tumors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| XELOX-A-Ev | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| capecitabine/oxaliplatin/bevacizumab/RAD001 (XELOX-A-Ev) | Drug | bevacizumab IV, capecitabine oral, oxaliplatin IV, RAD001 oral |
|
| Measure | Description | Time Frame |
|---|---|---|
| To determine the MTD/RPTD of capecitabine/oxaliplatin/bevacizumab/everolimus (XELOX-A-Ev) for subjects with advanced solid tumors. | End of treatment phase |
| Measure | Description | Time Frame |
|---|---|---|
| Describe dose-limiting and non-dose-limiting toxicities | End of treatment phase | |
| preliminarily investigate the response rate and PFS | from response to progression |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Herbert Hurwitz, MD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ingalls Cancer Research Center | Harvey | Illinois | 60426 | United States | ||
| Duke University Medical Center |
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| Durham |
| North Carolina |
| 27710 |
| United States |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | United States |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000069287 | Capecitabine |
| ID | Term |
|---|---|
| D003841 | Deoxycytidine |
| D003562 | Cytidine |
| D011741 | Pyrimidine Nucleosides |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005472 | Fluorouracil |
| D014498 | Uracil |
| D011744 | Pyrimidinones |
| D003853 | Deoxyribonucleosides |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
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