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The purpose of this study is to validate novel assays for serum biomarkers of lipid metabolism (PCSK9 and LDL receptor) and to obtain information about how these biomarkers differ in subjects with normal or high cholesterol levels
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blood draw (Group 1) | Other | Normocholesterolemic Subjects Normal Healthy Volunteers |
|
| Blood draw (Group 2) | Other | Hypercholesterolemic Subjects |
|
| Blood draw (Group 3) | Other | Hypercholesterolemic Subjects with Statin Treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draw | Procedure | 1 day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum PCSK9 concentration | Initial assessment will occur when Group 1 has 50 subjects enrolled and Groups 2 and 3 have 30 subjects enrolled |
| Measure | Description | Time Frame |
|---|---|---|
| Serum LDL cholesterol concentration | Initial assessment will occur when Groups 2 and 3 have enrolled 30 subjects | |
| Serum HDL cholesterol concentration | Initial assessment will occur when Groups 2 and 3 have enrolled 30 subjects |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bristol-Myers Squibb | Bristol-Myers Squibb | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Local Institution | Montreal | Quebec | H2W1R7 | Canada |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Serum TG concentration | Initial assessment will occur when Groups 2 and 3 have enrolled 30 subjects |
| Serum Apo B concentration | Initial assessment will occur when Groups 2 and 3 have enrolled 30 subjects |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |