Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)

Mapping Mood in the Subthalamic Nucleus in PD

The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).

Inclusion Criteria for STN-DBS subjects:

• Age 40 or older
• DBS STN Surgery in past 2 to 36 months
• Ability to tolerate turning off Stimulators
• Ability to read and comprehend questions
• English speaking

Exclusion Criteria for STN-DBS subjects:

• Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
• Clinically determined Dementia ( Most recent MMSE score of >24)

Inclusion Criteria for Control subject:

• Age 40 or older
• Ability to read and comprehend questions
• English speaking

Exclusion Criteria for Control subject:

• Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
• Clinically determined Dementia ( Most recent MMSE score of >24)
• Plans to have DBS STN surgery in the next 24 months