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Recent studies have shown that obese people are more prone to high blood pressure. With the co-existence of obesity, hypertension and diabetes, patients were more susceptible to hyperlipidemia, coronary and cerebral atherosclerosis and peripheral vascular disease. Abdominal obesity has often accompanied by substantial accumulation of visceral fat, which increased secretion of many inflammatory mediators, cytokines and adipocytokines and played an important role in cardiovascular and metabolic disease. Some reports had shown that angiotensin II receptor blockers (ARB) may improve metabolic profiles in patients with diabetes or metabolic syndrome, in addition to its hypotensive effect. It has been reported that some ARB, such as telmisartan and candesartan, can prevent weight gain and high-fat-induced obesity in experimental animals. However, whether telmisartan intervention on improvement of fat deposition and other related metabolic profiles is better than a CCB drugs (amlodipine) in those obese hypertensive patients with diabetes, was still unknown.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Telmisartan Group | Experimental | Telmisartan intervention group |
|
| Amlodipine Group | Active Comparator | Amlodipine intervention group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Temisartan | Drug | Temisartan, initial dose: 40 mg per day, Max dose: 160 mg per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure | Baseline, 24 weeks(End of trial) | |
| Metabolic profiles, including lipid profile and blood glucose | Baseline, 24 weeks(End of trial) |
| Measure | Description | Time Frame |
|---|---|---|
| Abdominal fat assessed by CT | Baseline, 24 weeks(End of trial) | |
| Obesity parameters, including waist circumference (WC) and body mass index (BMI) | Baseline, 24 weeks(End of trial) | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zhiming Zhu, MD, PhD | The third hospital affiliated to the Third Military Medical University. China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The third hospital affiliated to the Third Military Medical University | Chongqing | 400042 | China |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| D056128 | Obesity, Abdominal |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
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| ID | Term |
|---|---|
| D017311 | Amlodipine |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Amlodipine |
| Drug |
Amlodipine, initial dose: 5 mg per day, Max dose: 10 mg per day |
|
| Incidents of side effects between groups |
| Baseline, 24 weeks(End of trial) |
| D009748 |
| Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |