The purpose of this study is to examine the postprandial (anytime after a meal) effect of different dietary fats on endothelial function in HIV-infected and HIV-uninfected men.

This study requires two visits. Once determined eligible by the study criteria, during the first visit the participant will be randomly placed to receive one of two high-fat meals. The participant will receive the other study meal during the second visit. At each visit, brachial artery ultrasounds will be performed before and 3 hours after the meal is eaten. The sample size is 50 subjects. This study will be conducted at the Clinical Research Center at Tufts Medical Center.

Inclusion Criteria:

• HIV-positive white male aged >18 years

• Under one of the following treatment categories:

  • Treatment naive or have never taken any HIV medications
  • Taking Kaletra
  • Taking Sustiva
  • Taking Atripla

Exclusion Criteria:

• Smoker

• Pre-existing diagnosis or treatment for the following:

  • Lipid disorder
  • Cardiovascular disease
  • High blood pressure
  • Diabetes

• Acute opportunistic infection or malignancy within last 3 months or current therapy for either

• Active IV drug use

HIV-infected white males who have identified themselves with concerns about diet or cardiovascular disease.