Primary Objective:

To describe the immune response to a single administration of 2 formulations of the investigational cell-based influenza vaccines in healthy adult subjects.

Secondary Objective:

To describe the safety following a single administration of 2 formulations of the investigational cell-based influenza vaccines in healthy adult subjects.

This is a multi-center study in healthy adult subjects. All subjects will receive a single dose of one of the influenza vaccine formulations and will provide blood samples for immunogenicity assessment.

Inclusion Criteria :

• Healthy male or female subject, aged ≥ 18 to < 50 years on the day of inclusion
• Informed consent form signed
• Able to attend all scheduled visits and to comply with all trial procedures
• For a woman of childbearing potential: a negative urine pregnancy test and documented use of an effective method of contraception or abstinence for at least four weeks pre vaccination and up until three weeks post-vaccination

Exclusion Criteria :

• Subject currently breast-feeding.
• Participation in another clinical trial investigating a vaccine, drug, medical device, or medical procedure in the 4 weeks preceding the trial vaccination.
• Planned participation in another clinical trial during the present trial period.
• Prior participation in the Phase I trial of FLU INTERPAN (PER.C6) vaccine (study GCE01).
• Congenital or history of acquired immunodeficiency, or immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months.
• Systemic corticosteroid therapy as except the use of topical or inhalant corticosteroids
• Systemic hypersensitivity to egg proteins, chicken proteins, or to any of the vaccine components, or history of a life-threatening reaction to the trial vaccine or a vaccine containing the same substances.
• Chronic illness at a stage that could interfere with trial conduct or completion (chronic illness may include, but is not limited to, cardiac, renal or auto-immune disorders, or diabetes).
• Receipt of blood or blood-derived products in the 3 months preceding vaccination.
• Receipt of any vaccination in the 4 weeks preceding vaccination, or planned receipt of any vaccination in the 4 weeks following the trial vaccination.
• History of influenza infection (confirmed either clinically, serologically or microbiologically) within the 6 months preceding vaccination.
• Previous vaccination against influenza (in the 6 months preceding the trial vaccination).
• Planned receipt of any other 2007-2008 influenza vaccine.
• Thrombocytopenia or bleeding disorder contraindicating intramuscular (IM) vaccination.
• Subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent.
• History of Guillain-Barré syndrome
• Current abuse of alcohol or drug addiction that may interfere with the subject's ability to comply with trial procedures
• Any other condition which in the opinion of the investigator would pose a health risk to the participant or interfere with the evaluation of the vaccine.