The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3) factors considered to affect the safety and/or efficacy of this drug.

All the patients whom an investigator prescribes the first Macugen® should be registered consecutively until the number of subjects reaches target number in order to extract patients enrolled into the investigation at random.

Inclusion Criteria:

• Patients need to be administered Macugen® in order to be enrolled in the surveillance.

Exclusion Criteria:

• Patients not administered Macugen®.

The patients whom an investigator involving A5751033 prescribes the Macugen®).