The purpose of this study is to determine whether cultivated stem cell transplantation is effective for the treatment of patients wtih corneal stem cell deficiency.

Inclusion Criteria:

• Patients suffering from LSCD IIa and IIb. Those suffering from IIc may be included once inflammation has subsided and cornea can be staged as IIb.
• Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial.
• Women of child-bearing potential should use adequate contraception prior to study entry and for the duration of study participation

Exclusion Criteria:

• Subjects who are pregnant or lactating
• Subjects who have sensitivity to drugs that provide local anesthesia
• Subjects suffering from active infection of the external eye
• Medical conditions that prohibit the use of systemic immunosuppression (in cases of allogenic transplantation)