Treatment of Aggressive Localized Lymphoma

Phase III Study of the Interest of Radiotherapy After 4 or 6 Cycles of CHOP 14 Rituximab Regimen of Chemotherapy , Patients With Agressive Localized Lymphoma

Prospective and multicentric Phase III study, evaluation of the interest of the radiotherapy after 4 or 6 cycles of CHOP 14 R regimen of chemotherapy , patients with agressive and localized B lymphoma , age 18 to 75 years.

CHOP 14 R regimen of chemotherapy is a good standard in the treatment of agressive and localized B lymphoma.

Interest of the radiotheraphy

Inclusion Criteria:

• Age > 18 and < 75 years
• Diffuse B large cell lymphoma , CD 20+
• Ann Arbor stage I or II withe a bulk <7 cm
• stage i ou II confirmed by the PET-scan
• No previously treated
• HIV negative
• Signed Informed consent

Exclusion Criteria:

• Age< 18 and > 75 years
• other type of lymphoma
• CD20 negative
• Ann Arbor stage >II or bulk > 7 cm
• HIV positive
• Contraindication to Rituximab use according to Sm PC
• Containdication to antracyclin
• cancer or history of cancer , excepted in situ cancer of the cervix or skin epithelioma
• Refusal of sign the informed consent