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Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.
Even though studies suggest that elite sport can cause AHR and airway inflammation, more studies are needed to elucidate how and when AHR and airway inflammation develop; and there is a lack of follow-up studies. The present study will give us a chance to do a follow-up study to register changes in AHR and airway inflammation in athletes without any significant airway changes at baseline.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Swimmers |
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| Measure | Description | Time Frame |
|---|---|---|
| Airway responsiveness to eucapnic voluntary hyperpnea and methacholine | Three years |
| Measure | Description | Time Frame |
|---|---|---|
| Airway inflammation | Three years |
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Inclusion Criteria:
Exclusion Criteria:
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Participants were all elite swimmers and part of the Danish National Swimming Association's talent program for young swimmers at the baseline study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lars Pedersen, MD PhD | Contact | (+45) 35 31 30 69 | lars.pedersen@dadlnet.dk |
| Name | Affiliation | Role |
|---|---|---|
| Lars Pedersen, MD PhD | Respiratory and Allergy Research Unit, Bispebjerg Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital | Recruiting | Copenhagen | 2400 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18554704 | Background | Pedersen L, Lund TK, Barnes PJ, Kharitonov SA, Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol. 2008 Aug;122(2):322-7, 327.e1. doi: 10.1016/j.jaci.2008.04.041. Epub 2008 Jun 12. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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Blood (serum, whole blood) Exhaled breath condensate Induced sputum
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |