Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)

Study of the Effect of Treatment With Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure

The purpose of this study is to perform a randomized, controlled clinical trial to investigate if the phosphate binder sevelamer can improve insulin resistance and glucose handling in patients receiving maintenance hemodialysis.

Inclusion Criteria:

• Male or female patients 18-80 years of age with chronic renal failure treated with maintenance HD for >3 months.

Exclusion Criteria:

• Diabetes mellitus
• Treatment with sevelamer within 3 months prior to enrollment
• Acute, clinically significant inflammation within 1 month prior to enrollment
• Pregnancy or breast-feeding
• Clinically significant obstipation or bowel obstruction
• Discontinuation of previous sevelamer treatment because of side effects
• Expected time in HD < 1 year
• Unwillingness to undergo the investigations and follow-up required in the the protocol
• Patients who have received any investigational drug within 1 month prior to enrolment
• Participation in another study, which may interfere with the present study