Insulin Delivery Using Microneedles in Type 1 Diabetes

Insulin Delivery Using Microneedles in Type 1 Diabetes

The goal of this study is to determine if microneedles can effectively and painlessly deliver insulin to children and young adults with type 1 diabetes.

Inclusion Criteria:

• ≥ 8 years of age
• <19 years of age
• Type 1 Diabetes for at least 2 years
• Uses a conventional, FDA-approved insulin pump for the past year
• Uses Lispro insulin
• Mean hemoglobin A1C ≤ 8.5 % for the past year
• Body mass index ≤ 85th percentile for age
• Understand and be willing to adhere to the study protocol

Exclusion Criteria:

• Type 2 Diabetes
• Acanthosis nigricans
• Clinically significant major organ system disease
• On glucocorticoid therapy
• Insulin requirement ≥ 150 U/day
• Illness on the day of the study
• Cognitive impairment (IQ < 85 or > 2 grades behind age-appropriate grade)
• Pregnant or breast-feeding (if female).