Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury

A Randomized Controlled Multi-Center Trial of the Early Application of CRRT in Patients With Severe Sepsis or Septic Shock

Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy. But there is no consensus for proper time of CRRT may improve the prognosis.

The study is a prospective randomized one center trial comparing two treatments in patients suffering from septic shock complicated with acute renal failure admitted to ICU, treated either early by CRRT (35 ml/kg/h) or by conventional RRT.

Inclusion Criteria:

• Septic shock (Bone criteria) for less than 14D
• RIFLE criteria : Injury or Failure or nearly anuria more than 2hr
• Age over 18 years
• Written informed consent by next of kin.

Exclusion Criteria:

• Cirrhosis child class C
• CRF or ESRD
• Too high APACHE II & SOFA score at admission
• Age over 80 years
• Life expectancy less than 3 months (metastatic cancer - hepatoma, lung ca.)