Investigation of Rate+Extent of Excretion of Radioactivity in Urine+Faeces After Oral Administration of [14C]AZD1386

An Open, Single Dose, Phase I Study of the Excretion of Radioactivity, Metabolism and Pharmacokinetics Following Oral Administration of [14C]AZD1386 to Healthy Male Volunteers

The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD1386 in healthy male volunteers.

Inclusion Criteria:

• Body Mass Index of 18 - 30 and weight of 50 to 100 kilos.
• Healthy volunteer must have regular bowel movements (at least once daily)

Exclusion Criteria:

• History of psychiatric or somatic disease/condition, which may interfere with the objectives of the study as judged by the investigator.
• A family history of short QT syndrome or sudden cardiac death amongst first degree relatives.
• Any clinically important abnormalities in heart rhythm, conduction or morphology of resting ECG that may interfere with the interpretation of QTc interval changes.