The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD1386 in healthy male volunteers.

Inclusion Criteria:

• Body Mass Index of 18 - 30 and weight of 50 to 100 kilos.
• Healthy volunteer must have regular bowel movements (at least once daily)

Exclusion Criteria:

• History of psychiatric or somatic disease/condition, which may interfere with the objectives of the study as judged by the investigator.
• A family history of short QT syndrome or sudden cardiac death amongst first degree relatives.
• Any clinically important abnormalities in heart rhythm, conduction or morphology of resting ECG that may interfere with the interpretation of QTc interval changes.