Phase I Combination Ixabepilone + Cisplatin

Phase 1 Study of Ixabepilone in Combination With Cisplatin in Subjects With Advanced Solid Tumors

The purpose of this study is to determine the highest dose of ixabepilone that can be given safely with cisplatin without causing severe or life-threatening side effects and for some patients with non-small cell lung cancer, the effects (good or bad) on your cancer will also be studied

Escalation Phase Subjects: Primary solid tumor not curable by local measures such as surgery, radiation

Inclusion Criteria:

• Men and women age ≥ 18

Exclusion:

• More than 2 prior chemotherapy containing regimens for metastatic disease
• No prior exposure to cisplatin or ixabepilone

Expansion Phase Subjects: Advanced Non-small cell lung cancer

Inclusion Criteria:

• Men and women age ≥ 18

Exclusion:

• No prior chemotherapy-containing regimen for metastatic disease
• No prior exposure to cisplatin or ixabepilone