Safety and Tolerability of Dimebon in Patients on Memantine, and Memantine Plus Donepezil

A Multi-Center Phase 1 Study of the Safety and Tolerability of Dimebon in Alzheimer's Disease Patients on Memantine (Cohort 1) and Memantine Plus Donepezil (Cohort 2)

The purpose of this study is to evaluate the safety and tolerability of dimebon given to Alzheimer's disease patients currently on a stable dose and regimen of memantine or memantine plus donepezil.

Inclusion Criteria:

• Alzheimer's disease
• On Memantine
• Caregiver who is willing to accompany the patient to all clinic visits

Exclusion Criteria:

• Unstable medical illnesses or significant hepatic or renal disease
• Other primary psychiatric or neurological disorders