Impact of Three Different Gonadotrophin Regimes on Egg Donation Program

A Prospective, Randomized, Controlled Trial Comparing Three Different Gonadotrophin Regimens in Oocyte Donors: Ovarian Response and IVF Outcome

Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol). 1,028 donors were randomized in three groups: Group I (n= 346) only r-FSH, Group II (n= 333) only HP-hMG and Group III (n= 349) r-FSH plus HP-hMG. IVF outcome of 1,059 oocyte recipients was compared.

Inclusion Criteria:

• healthy women 18-34 years of age
• regular menstrual cycles
• no family history of hereditary or chromosomal diseases
• normal karyotype
• BMI 18-29 Kg/m2
• negative screening for sexually transmitted diseases

Exclusion Criteria:

• women with PCOS were not included in this study