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This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.
The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated across up to 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal includes the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Other | Repeated probes every 8 hours of treatment (1/week) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| One-on-one treatment of reading difficulties | Behavioral | Multimodal behavioral treatment focused on retraining sound to letter associations and skills in sounding out words when reading. Treatment has been pilot-tested in published papers since 1998. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Real World Reading Skills | Real World Reading Skills was tested using the Woodcock Reading Mastery Test-Revised | Language testing are conducted two weeks prior to treatment, immediately following end of treatment and 3 months after end of treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Timothy W. Conway, PhD | North Florida/South Georgia Veterans Health System | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| North Florida/South Georgia Veterans Health System | Gainesville | Florida | 32608 | United States |
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| Label | URL |
|---|---|
| Dr. Conway's homepage | View source |
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| D020521 | Stroke |
| D004411 | Dyslexia, Acquired |
| D004410 | Dyslexia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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This is a repeated probe design study.
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| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000067559 | Specific Learning Disorder |
| D007859 | Learning Disabilities |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D065886 | Neurodevelopmental Disorders |