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Objective: To study the effect of fast food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC)and metabolism.
Design: Prospective interventional study with parallel control group. Setting University Hospital of Linköping, Sweden. Participants: 12 healthy men and six healthy women with a mean (SD) age of 26 (6.6) years and a matched control group.
Intervention: Subjects in the intervention group aimed for a body weight increase of 5-15% by eating at least two fast food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks.
Main outcome measures: Weekly changes of serum aminotransferases and HTGC measured by proton nuclear magnetic resonance-spectroscopy at baseline and after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Fast food intake, doubling of caloric intake, in combination with sedentary behavior (no exercise) |
|
| 2 | No Intervention | Control group, parallel |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fast food arm | Procedure | Doubling of regular caloric intake based on fast food, no exercise allowed |
|
| Measure | Description | Time Frame |
|---|---|---|
| weight gain | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Linkoping | Linköping | 58185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18276725 | Result | Kechagias S, Ernersson A, Dahlqvist O, Lundberg P, Lindstrom T, Nystrom FH; Fast Food Study Group. Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects. Gut. 2008 May;57(5):649-54. doi: 10.1136/gut.2007.131797. Epub 2008 Feb 14. | |
| 20814413 | Derived |
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| ID | Term |
|---|---|
| D001835 | Body Weight |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
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| Lindstrom T, Kechagias S, Carlsson M, Nystrom FH; Fast Food Study Group. Transient increase in HDL-cholesterol during weight gain by hyperalimentation in healthy subjects. Obesity (Silver Spring). 2011 Apr;19(4):812-7. doi: 10.1038/oby.2010.190. Epub 2010 Sep 2. |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |