Uveitic Cystoid Macular Edema (CME) is a major cause of visual loss associated with uveitis. Systemic and/or local corticosteroid therapy and systemic immunosuppression with steroid-sparing agents such as cyclosporine, methotrexate, azathioprine, or others, effectively treats uveitis and associated CME in many patients. However, in many cases, CME persists in spite of adequate suppression of uveitis. No consensus exists on how best to treat such cases. The further addition of immunosuppressive agents appears to have little effect on this form of CME. Oral corticosteroids are useful, but high dosage and prolonged use can be associated with serious side-effects. Periocular and intravitreal corticosteroid injections are associated with well-known, significant side effects such as glaucoma and cataract formation.

Vascular endothelial growth factor (VEGF) is suspected to play a role in the loss of vascular integrity in the eye and known to be induced by inflammatory cytokines, such as interleukin interleukin (IL)-1β and IL-6, which are elevated intraocularly in uveitis. In addition, it has been demonstrated that aqueous VEGF concentrations are statistically significantly higher in those uveitis patients with CME than those without CME. Inhibition of inappropriate VEGF activity is a potential approach to treatment of CME in uveitis given our current knowledge of the pathophysiology of this condition and also because of the clinical need for additional treatment options for these patients. Ranibizumab, a recombinant, humanized monoclonal antibody antigen-binding fragment (Fab) that neutralizes all active forms of VEGF-A, would target this pathway and may be useful in cases of persistent CME in uveitis patients.

The objective of this study is to determine if an anti-VEGF agent, Lucentis, is safe and effective in leading to regression of macular edema due to chronic non-infectious uveitis in patients with well-controlled uveitis.

Inclusion Criteria:

Subjects will be eligible if the following criteria are met:

1. Ability to provide written informed consent and comply with study assessments for the full duration of the study.
2. Age > 18 years
3. Non-infectious uveitis in study eye.
4. Stable anti-uveitis medical regimen for at least one month prior to injection and controlled uveitis in the judgment of the investigator.
5. Vision 20/40 or worse in study eye.
6. Cystoid Macular Edema (CME) on fluorescein angiography (FA)
7. Optical Coherence Tomography (OCT) demonstrating thickness greater than 300 microns in the central subfield.
8. Media clarity, pupillary dilation and patient cooperation sufficient to allow OCT testing and retinal photography.

Only one eye will be assessed in the study. If both eyes are eligible, the investigator will determine which eye will be entered into the study.

Exclusion Criteria:

1. Previous intravitreal triamcinolone injection in study eye within 3 months of study injection.
2. Use of more than two glaucoma medicines for study eye.
3. Significant epiretinal membrane as judged by treating physician.
4. Evidence of vitreomacular traction on OCT.
5. Previous vitrectomy in study eye.
6. Pregnancy (positive pregnancy test) or lactation.
7. Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an intrauterine device (IUD), or contraceptive hormone implant or patch.
8. Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated.
9. Participation in another simultaneous IND trial.
10. Treatment for CME with intravitreal Lucentis, Macugen, or Avastin within 6 weeks prior to enrollment in this study.
11. Uncontrolled inflammation in the study eye.
12. Current vitreous hemorrhage.
13. Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye.
14. Known allergy to any component of the study drug.
15. Intraocular pressure > 25 mm Hg despite treatment with glaucoma medications.
16. Blood pressure > 180/110 (systolic above 180 OR diastolic above 110). If blood pressure is brought below 180/110 by anti-hypertensive treatment, the subject can become eligible.
17. Major non-ocular surgery planned during the next 6 months.
18. Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated.
19. No Avastin use permitted in fellow eye during study.
20. Unwilling or unable to follow or comply with all study related procedures

The main limitation of this study is the small number of patients.There is no comparative arm to better define the relative efficacy of ranibizumab as compared with intraocular steroids or other treatments.