Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The Danish Medical Research Council | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim was to determine the wound healing capacity in healthy never smokers and smokers who continue to smoke, or quit smoking using transdermal nicotine patch versus placebo patch.
Two wound healing models were applied: the excisional skin biopsy model to study wound histology and the suction blister model to study epidermal regeneration and skin transudate. In addition blood sampling was made to validate compliance to the study arms and to study systemic markers of collagen metabolism and oxidative stress. In addition, wound infections and wound ruptures were recorded post hoc as complications to the excisional skin biopsy model were not expected to occur.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| continuous smoking | Active Comparator | subjects smoke 20 cigarettes per day |
|
| smoking cessation and NRT | Active Comparator | subjects quit smoking and use transdermal nicotine patch |
|
| smoking cessation and placebo patch | Placebo Comparator | subjects quit smoking and use placebo patch |
|
| never smokers | No Intervention | subjects being never smokers and who refrain from smoking |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transdermal nicotine patch | Drug | 15mg/16h + 10mg/16h to be used 24h |
|
| Measure | Description | Time Frame |
|---|---|---|
| wound healing | 1, 4, 8, and 12 weeks |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Lars T Sorensen, MD | Bispebjerg Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | 2400 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12832959 | Result | Sorensen LT, Karlsmark T, Gottrup F. Abstinence from smoking reduces incisional wound infection: a randomized controlled trial. Ann Surg. 2003 Jul;238(1):1-5. doi: 10.1097/01.SLA.0000074980.39700.31. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D061485 | Tobacco Use Cessation Devices |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo patch | Drug |
|
| Smoking cessation | Behavioral |
|
| Continuous smoking | Behavioral | subjects smoke 20 cigarettes per day |
|