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| ID | Type | Description | Link |
|---|---|---|---|
| 2008-03 |
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Natural Killer (NK) cells play a unique role during innate immune responses as they are able to recognize and eliminate, without specific sensitization, tumors, microbe-infected cells as well as allogeneic cells.In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin.
Then, we will define whether these parameters are qualitatively/ quantitatively modified in the following skin pathologies: a) atopic dermatitis; b) contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH (graft versus host disease) ; (f) melanoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | Healthy volunteer |
|
| 2 | Other | atopic dermatitis patient |
|
| 3 | Other | contact dermatitis patient |
|
| 4 | Other | psoriasis patient |
|
| 5 | Other | lichen planus patient |
|
| 6 | Other | GVH patient |
|
| 7 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
| |
| Biopsy and sample of blood |
| Measure | Description | Time Frame |
|---|---|---|
| In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| To determine whether the eventual modifications detected in skin pathologies are correlated to qualitative/ quantitative alterations of NK cell subsets present in the peripheral blood. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Caroline Gaudy-Marqueste, MD | Assistance Publique des Hopitaux de Marseille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Dermatologie- Hopital Sainte Marguerite | Marseille | 13385 | France |
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melanoma patient |
|
| Other |
Biopsy and sample of blood |
|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
|
| Biopsy and sample of blood | Other | Biopsy and sample of blood |
|
| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| D003877 | Dermatitis, Contact |
| D011565 | Psoriasis |
| D008010 | Lichen Planus |
| D006086 | Graft vs Host Disease |
| D008545 | Melanoma |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D017444 | Skin Diseases, Papulosquamous |
| D017512 | Lichenoid Eruptions |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D001706 | Biopsy |
| ID | Term |
|---|---|
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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