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Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.
The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Cumulative Fentanyl Consumption | 24 hr after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Cumulative Fentanyl Consumption | 48hr after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Gynecologic patients undergoing total abdominal hysterectomy or laparoscpy assisted vaginal hysterectomy under general anesthesia
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| Name | Affiliation | Role |
|---|---|---|
| Kye-Min Kim, MD. PhD. | Department of Anesthesia, Inje University Sanggye Paik Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inje University Sanggye Paik Hospital | Seoul | 139-707 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23557865 | Derived | Kim KM, Kim HS, Lim SH, Cheong SH, Choi EJ, Kang H, Choi HR, Jeon JW, Yon JH, Oh M, Shin JG. Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients. Int J Clin Pharmacol Ther. 2013 May;51(5):383-92. doi: 10.5414/CP201824. |
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No group assignment required for this study.
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| ID | Title | Description |
|---|---|---|
| FG000 | Gynecologic Patients Undergoing TAH, LAVH |
|
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Gynecologic Patients Undergoing TAH, LAVH |
|
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Postoperative Cumulative Fentanyl Consumption | Posted | Mean | Standard Deviation | mcg | 24 hr after surgery |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Gynecologic Patients Undergoing TAH, LAVH |
|
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Kye-Min Kim, Associate Professor, Dept of Anesthesiology & Pain Medicine | Inje University | 82-2-950-1168 | kyemin@paik.ac.kr |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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whole blood
| Participants |
|
| Age Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
| Secondary | Postoperative Cumulative Fentanyl Consumption | Posted | Mean | Standard Deviation | mcg | 48hr after surgery |
|
|
|
| 0 |
| 204 |
| 0 |
| 204 |
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| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |