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| ID | Type | Description | Link |
|---|---|---|---|
| SJ-98 |
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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Hagedorn Research Institute | OTHER |
| The Novo Nordisk Foundation Center for Basic Metabolic Research | OTHER |
| Herlev Hospital |
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Definition:
the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity.
The specific aims are to;
(hypothesis; the intervention could reduce the liver fat percentage and a reduction in BMI SDS would associate with a reduction in liver fat content) - Analyze changes in liver fat content in relation to changes in levels of fasting blood variables to see if any of them could be used as a clinical tool for monitoring hepatic steatosis in the clinic.
(hypothesis; serum aminotransferases (separately and their ratio, respectively), serum insulin, and HOMA-IR could predict improvement in liver fat content
- Investigate the association between genetic variants and obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Overweight and obese Children (BMI SDS > 90th percentile according to Danish BMI sheets) 5-20 Years of age. Recruited from the Paediatric department, University Hospital Holbaek, Region Zealand, Denmark, University of Copenhagen |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chronic care multidisciplinary intervention of childhood obesity | Other | Overweight and obese Children, 5-20 Years old, followed by Paediatricians and other Health Personals (multidisciplinary team). Included at their first visit in the clinic (baseline)and follow-up after ~ 1 Year. |
| Measure | Description | Time Frame |
|---|---|---|
| weightloss | 1 Year |
| Measure | Description | Time Frame |
|---|---|---|
| NAFLD (non-alcoholic Fatty Liver Disease).Gene-polymorphs | Nafld measured by Magnet resonance spectroscopy. Sequencing of MC4R | 1 Year |
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Inclusion Criteria:
Exclusion Criteria:
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Overweight and obese Children. 5-20 Years old. Paediatric Department, University Hospital Holbaek,Region Zealand, University of Copenhagen, Denmark
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| Name | Affiliation | Role |
|---|---|---|
| Dorthe S. Bille, MD | Paediatric department, University Hospital Holbaek, Region Zealand, University of Copenhagen, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Children's Obesity Clinic, Paediatric Department, University Hospital Holbaek, Region Zealand, University of Copenhagen | Holbæk | 4300 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21377308 | Result | Chabanova E, Bille DS, Thisted E, Holm JC, Thomsen HS. MR spectroscopy of liver in overweight children and adolescents: investigation of (1)H T(2) relaxation times at 3T. Eur J Radiol. 2012 May;81(5):811-4. doi: 10.1016/j.ejrad.2011.02.017. Epub 2011 Mar 4. | |
| 22736224 | Result | Chabanova E, Bille DS, Thisted E, Holm JC, Thomsen HS. (1)H MRS assessment of hepatic steatosis in overweight children and adolescents: comparison between 3T and open 1T MR-systems. Abdom Imaging. 2013 Apr;38(2):315-9. doi: 10.1007/s00261-012-9930-2. |
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| OTHER |
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Blood samples of Whoole Blood.
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| 25586046 | Result | Bille DS, Chabanova E, Gamborg M, Fonvig CE, Nielsen TR, Thisted E, Thomsen HS, Holm JC. Liver fat content investigated by magnetic resonance spectroscopy in obese children and youths included in multidisciplinary treatment. Clin Obes. 2012 Feb;2(1-2):41-9. doi: 10.1111/j.1758-8111.2012.00038.x. Epub 2012 Apr 24. |
| ID | Term |
|---|---|
| D063766 | Pediatric Obesity |
| D065626 | Non-alcoholic Fatty Liver Disease |
| D006973 | Hypertension |
| D006949 | Hyperlipidemias |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
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