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This is a four week open label trial of ALLOPURINOL to the treatment regime of ten (10) poorly responsive patients with schizophrenia, monitoring their response and side-effects. No change in medication is required.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Allopurinal treatment | Experimental | Allopurinal 300mg once daily by mouth for four weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allopurinal | Drug | 300mg once daily by mouth for four weeks |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Positive and Negative Syndrome Scale (PANSS) Measures Symptoms of Schizophrenia | Symptom scale Score 30 (best, no symptoms of schizophrenia) to 210 (worst) | baseline and 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Simpson Angus Scale for Parkinsonism | Measures drug induced parkinsonism, score 0 (best, no Parkinsonism) to 36 (worst) | baseline and 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nigel Bark, MD | Bronx Psychiatric Center | Principal Investigator |
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Ten subjects were recruited, in-patients in a State Hospital, between 2005 and 2008
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| ID | Title | Description |
|---|---|---|
| FG000 | Allopurinal Treatment |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Group 1 | All participants |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change in Positive and Negative Syndrome Scale (PANSS) Measures Symptoms of Schizophrenia | Symptom scale Score 30 (best, no symptoms of schizophrenia) to 210 (worst) | Two subjects withdrew before the first week's evaluation | Posted | Mean | Standard Deviation | scores on a scale | baseline and 4 weeks |
|
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During the 4 week study
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Group 1 | All participants |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Nigel Bark MD | Bronx Psychiatric Center | 7188625429 | Nigel.Bark@omh.ny.gov |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Secondary | Simpson Angus Scale for Parkinsonism | Measures drug induced parkinsonism, score 0 (best, no Parkinsonism) to 36 (worst) | Posted | Mean | Standard Deviation | score on scale | baseline and 4 weeks |
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| Post-Hoc | Uric Acid Level | 2 subjects had missing data | Posted | Mean | Standard Deviation | mg/dL | Baseline and 4 weeks |
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| 0 |
| 10 |
| 0 |
| 10 |
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