Botulinum A Toxin in Patients With Parkinson's Disease

The Use of Toxin Botulinum A Toxin in Patients With Parkinson's Disease and Multiple System Disease, Affected by Refractory Detrusor Overactivity.

The researchers investigated the effectiveness and safety of BoNT/A injected into the detrusor muscle in patients with PD and MSA all of whom had detrusor muscle overactivity unresponsive to conventional medical therapy.

Patients included will have overactive bladder symptoms refractory to medical therapy. Other causes of overactive bladder symptoms including urogenital prolapse and recurrent urinary tract infections were excluded. None of the patients will be under anticoagulant therapy or drugs interfering with neuromuscular transmission. The study was approved by the local ethical committee and patients gave their informed consent. Patients will be informed about the possible need for intermittent catheterization after BoNT/A treatment.

As outcome measures we assessed clinical and urodynamic variables.

Inclusion Criteria:

• Patients with overactive bladder symptoms refractory to medical therapy.

Exclusion Criteria:

• Other causes of overactive bladder symptoms including urogenital prolapse and recurrent urinary tract infections were excluded.
• Concomitant anticoagulant therapy or drugs interfering with neuromuscular transmission.
• Neuromuscular disease like Lambert-Eaton syndrome.