Bone Marrow Autotransplantation in Type 1 Diabetes

Regeneration of Insulin Production in Patients With Type 1 Diabetes by Autologous Bone Marrow Blood Infusion

This project evaluates the effectiveness of the administration of autologous bone marrow blood in patients with brittle type 1 diabetes mellitus to restore insulin secretion. After mobilization of hematopoietic progenitors (G-CSF) during 3 days, 50 to 90 mL of bone marrow blood will be obtained by multifunction in the posterior iliac crest. The material obtained will be implanted into the pancreas through the magna pancreatic artery after femoral catheterization.

Inclusion Criteria:

• diabetes type 1 patients
• 18 to 50 years of age
• more than 5 years of evolution of the disease
• brittle diabetes (HbA1c > 8.5 % with intensified treatment or severe hypoglycemia episodes

Exclusion Criteria:

• history of cancer
• hematologic alterations
• infectious disease positivity (HIV, HCV etc.)
• diabetic nephropathy
• cardiac failure
• liver disease
• autoimmune systemic disease
• allergy to iodine contrast or anesthesia