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This project evaluates the effectiveness of the administration of autologous bone marrow blood in patients with brittle type 1 diabetes mellitus to restore insulin secretion. After mobilization of hematopoietic progenitors (G-CSF) during 3 days, 50 to 90 mL of bone marrow blood will be obtained by multifunction in the posterior iliac crest. The material obtained will be implanted into the pancreas through the magna pancreatic artery after femoral catheterization.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| administration of autologous bone marrow blood | Biological | administration of autologous bone marrow blood through magna pancreatic artery after femoral catheterization once during 12-month study period |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate glycosylated hemoglobin 1,3,6, and 12 months after autologous bone marrow blood administration. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate number of hypoglycemias 1,3,6, and 12 months after autologous bone marrow blood administration. | 12 months | |
| Evaluate insulin dose 1,3,6, and 12 months after autologous bone marrow blood administration. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Esmatjes Enric, MD | Hospital Clinic of Barcelona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Enric Esmatjes | Barcelona | Barcelona | 08036 | Spain | ||
| Hospital Clinic |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20101385 | Derived | Esmatjes E, Montana X, Real MI, Blanco J, Conget I, Casamitjana R, Rovira M, Gomis R, Marin P. Regeneration of insulin production by autologous bone marrow blood autotransplantation in patients with type 1 diabetes. Diabetologia. 2010 Apr;53(4):786-9. doi: 10.1007/s00125-010-1660-9. Epub 2010 Jan 26. No abstract available. |
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| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Evaluate GADab titers and treatment tolerance 1,3,6, and 12 months after autologous bone marrow blood administration. | 12 months |
| Barcelona |
| Barcelona |
| 08036 |
| Spain |
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |