Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia

Beta-lactam Monotherapy Versus Beta-lactam - Macrolide Association as Empiric Antibiotherapy Strategies in Non-severe Hospitalized Community-acquired Pneumonia: a Randomized, Non-inferiority, Open Trial.

The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with community-acquired pneumonia.

Inclusion Criteria:

• Age >=18 years
• New infiltrate on chest X-ray, unexplained by another disease process
• Presence of at least two of the following findings suggestive of pneumonia: fever or hypothermia, new or increasing cough, sputum production, pleuritic chest pain, tachypnea, dyspnea or focal signs on chest examination
• Need for hospitalization as defined by the emergency physician in charge of the patient

Exclusion Criteria:

• Allergy to one of the study drugs
• Pregnancy
• Severe immunosuppression
• Recent (<14 d) hospitalization, or currently hospitalized since > 48 hours
• Residency in a nursing home
• Previous use of more than 24 hours of any antibiotic
• Severe community-acquired pneumonia