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| Name | Class |
|---|---|
| University Hospital, Geneva | OTHER |
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The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with community-acquired pneumonia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Monotherapy | Experimental |
| |
| Bi-therapy | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beta lactam (amoxicillin / clav. acid OR cefuroxime) | Drug | 1.2 g 4x/d OR 1.5 g 3x/d IV |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to Clinical Stability (hours) | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| All cause mortality | in-hospital, at 30 and at 90 days | |
| length of stay | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arnaud Perrier, MD | University of Geneva and University Hospital of Geneva | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HFR-Fribourg, Hôpital Cantonal | Fribourg | Canton of Fribourg | 1708 | Switzerland | ||
| Stadtspital Triemli |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35505308 | Derived | Chauffard A, Bridevaux PO, Carballo S, Prendki V, Reny JL, Stirnemann J, Garin N. Accuracy of a score predicting the presence of an atypical pathogen in hospitalized patients with moderately severe community-acquired pneumonia. BMC Infect Dis. 2022 May 3;22(1):424. doi: 10.1186/s12879-022-07423-1. | |
| 25286173 | Derived |
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| Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin) | Drug | 1.2 g 4x/d OR 1.5 g 3x/d IV AND 0.5 g 2x/d IV/PO |
|
|
| Zurich |
| Canton of Zurich |
| 8063 |
| Switzerland |
| Centre Hospitalier du Centre du Valais | Sion | Valais | 1950 | Switzerland |
| Hôpitaux Universitaires de Genève | Geneva | 1211 | Switzerland |
| Hôpital Neuchâtelois - La Chaux-de-Fonds | La Chaux-de-Fonds | 2300 | Switzerland |
| Centre Hospitalier Universitaire Vaudois | Lausanne | 1011 | Switzerland |
| Garin N, Genne D, Carballo S, Chuard C, Eich G, Hugli O, Lamy O, Nendaz M, Petignat PA, Perneger T, Rutschmann O, Seravalli L, Harbarth S, Perrier A. beta-Lactam monotherapy vs beta-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial. JAMA Intern Med. 2014 Dec;174(12):1894-901. doi: 10.1001/jamainternmed.2014.4887. |
| ID | Term |
|---|---|
| D000098968 | Community-Acquired Pneumonia |
| D017714 | Community-Acquired Infections |
| D011014 | Pneumonia |
| ID | Term |
|---|---|
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D047090 | beta-Lactams |
| D000658 | Amoxicillin |
| D002444 | Cefuroxime |
| D019980 | Amoxicillin-Potassium Clavulanate Combination |
| D018942 | Macrolides |
| D017291 | Clarithromycin |
| ID | Term |
|---|---|
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D000667 | Ampicillin |
| D010400 | Penicillin G |
| D010406 | Penicillins |
| D002511 | Cephalosporins |
| D013843 | Thiazines |
| D019818 | Clavulanic Acid |
| D002969 | Clavulanic Acids |
| D004338 | Drug Combinations |
| D004364 | Pharmaceutical Preparations |
| D007783 | Lactones |
| D061065 | Polyketides |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
| D004917 | Erythromycin |
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