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| ID | Type | Description | Link |
|---|---|---|---|
| 5RO1DK71696-4 | |||
| 5R01DK071696 | U.S. NIH Grant/Contract | View source |
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This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline | No Intervention | CKD subjects and healthy, matched controls will have measures of cardiovascular function (BP, HR) measure of hormonal fluid balance (renin/aldosterone) measure and measures of glucose metabolism (response to glucose load and over 24 hr profile) with 3 days of habitual sleep time | |
| CKD- Sleep extension | Experimental | Measures as in baseline but with bed time increased by 2 hours |
|
| Controls short sleep | Experimental | Measures as in baseline but with sleep disruption |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Controls Short sleep | Other | Healthy control subject's bedtime will be decreased by 2 hours/night with acoustic sleep disruption |
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| Measure | Description | Time Frame |
|---|---|---|
| Comparison of chronobiological profiles of renin/aldosterone, sympatho-vagal balance and CV function in CKD subjects to controls at baseline and after extended sleep in CKD subjects and after decreased time and quality of sleep in control subjects. | Immediately after intervention. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eve Van Cauter, PhD | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Chicago | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| CKD- sleep extension | Other | Sleep will be increased by 2 hours each night for 3 nights |
|
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| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |