A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064)

A Randomized, Single-Blind, Placebo-Controlled, Single-dose, Parallel Design Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (FSR)

This is a study to evaluate the use of fractional synthetic rate as an early biomarker of muscle anabolism (muscle build-up).

Inclusion Criteria:

• Subject is weight stable over the past 3 months
• Patient agrees to refrain from consumption of alcohol from 48 hours prior to entering the study
• Subject agrees to follow the study restriction of no caffeine while on study
• Patient agrees to following the meat-free controlled protein weight-maintaining diet
• Patient is willing to avoid strenuous physical activity
• Patient has been a nonsmoker for at least 6 months prior to study start

Exclusion Criteria:

• Subject is currently a regular user of any illicit drugs
• Subject has taken androgenic steroids in the previous 12 months
• Subject has participated in sports events, resistance exercise training or heavy exercise in the previous month
• Subject has prostate cancer
• Subject has a history of cancer except basal-cell tumors
• Subject has been diagnosed with HIV
• Subject has been diagnosed with Hepatitis B or C
• Subject uses certain anti-inflammatory drugs such as ibuprofen, arcoxia or celecoxib
• Subject uses a blood anticoagulant, such as Coumadin (Warfarin) or high doses of aspirin
• Subject is currently taking over the counter supplements such as "muscle builders" or "fat burners"
• Subject has an allergy or hypersensitivity to intramuscular testosterone
• Subject has sciatica
• Subject has donated blood products or has had phlebotomy within 2 months of signing informed consent
• Subject has undergone a surgical procedure within 1 month of signing informed consent
• Subject is currently participating or has participated in a study with an investigational drug or device